af·flic·tion
–noun
1.
a state of pain, distress, or grief; misery: They sympathized with us in our affliction.
2.
a cause of mental or bodily pain, as sickness, loss, calamity,or persecution.
—Synonyms mishap, trouble, tribulation, calamity, catastrophe, disaster.Affliction, adversity, misfortune, trial refer to an event orcircumstance that is hard to bear. A misfortune is any adverse orunfavorable occurrence: He had the misfortune to break his leg.Affliction suggests not only a serious misfortune but the emotionaleffect of this: Blindness is an affliction. Adversity suggests acalamity or distress: Job remained patient despite all hisadversities. Trial emphasizes the testing of one's character inundergoing misfortunes, trouble, etc.: His son's conduct was agreat trial to him.